Table 1.
Summary of some biochemical, functional and structural characteristics patients infected by the dengue virus
| Parameters | Control | Case 1 | Case 2 | Case 3 | Case 4 | Case 5 |
|---|---|---|---|---|---|---|
| Fg (g/l) | 3.2 | 3.2 | 2.6 | 2.5 | 2.6 | 2.5 |
| TT (s) | 19.9 | 22 | 23.3 | 25.6 | 27 | 38.4 |
| D-dimer (ng/ml) | 625 | 375 | 1300 | 6000 | 750 | 1600 |
| Albumin (%) | 100 | 166 | 166 | 132 | 116 | 108 |
| Polymerization | ||||||
| Lag Time (s) | 0 | 30 | 50 ± 9 | 25 ± 17 | 70 ± 9 | 35 ± 9 |
| Slope (OD unit/s) × 10−3 | 1.9 ± 0.1 | 2.6 ± 0.1 | 2.2 ± 0.2 | 1.9 ± 0.3 | 1.9 ± 0.0 | 1.4 ± 0.0 |
| Maximum ι (OD unit) | 0.230 ± 0.006 | 0.179 ± 0.002 | 0.198 ± 0.009 | 0.203 ± 0.009 | 0.128 ± 0.004 | 0.131 ± 0.005 |
| Fibrinolysis | ||||||
| TLT (s) | 548 ± 11 | 550 ± 9 | 550 ± 17 | 580 ± 23 | 580 ± 23 | 548 ± 11 |
| V (OD unit/s) 10−5 | 100 ± 5 | 70 ± 3 | 90 ± 2 | 70 ± 2 | 50 ± 4 | 50 ± 0.3 |
| t½ (s) | 462 ± 5 | 463 ± 9 | 450 ± 20 | 438 ± 23 | 495 ± 20 | 450 ± 11 |
| (ιf/ιp) × 100 | 98 ± 5 | 68 ± 2 | 83 ± 4 | 71 ± 3 | 87 ± 2 | 67 ± 8 |
| Fiber diameter (nm) | 97 ± 31 | 112 ± 44* | 117 ± 40* | ND | 113 ± 35* | 104 ± 37* |
Fibrinogen concentration was determined by the gravimetric method, albumin was quantified by immunoelectrophoresis and fibrin polymerization and lysis process was measured by turbidity at 350 nm. The mean average of fibrin fibers thickness was calculated from digitized scanning electron microscopy pictures using ImageJ 1.36b software. ND, not done; ι, turbidity; ιf/ιp, ratio between maximum turbidity of fibrinolysis and polymerisation; t½, time to reach 50% of clot degradation; TLT, total lysis time; V, lysis rate.
*
Statistically significant.