Figure 5. Effects of the dj-1β mutation on mtROS production and lifespan in Drosophila melanogaster.

(A) mtROS production, assayed as H₂O₂, (mean + SEM). a, b and c denote statistically significant differences between groups (ANOVA, p<0.05, n = 4-6 samples per group), m: male, f: female. (B) Survival curves. Combined data from two independent experiments using 100 flies per group per experiment. Mean, maximum lifespans (d) were: DAH males (43, 58); DAH females (75, 79); dj-1β mutant males (67, 75); dj-1β mutant females (79, 86).