Table 1.
Power increment by taking repeated measures (scenario 2)
| Polygene effect (% total var.) | No measurement error or M = ∞ |
M = 4 |
M = 2 |
M = 1 |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| ELOD | power | ratio | ELOD | power | ratio | ELOD | power | ratio | ELOD | power | |
| 0.0 (0%) | 4.88 | 0.94 | 2.71 | 3.58 | 0.80 | 1.99 | 2.74 | 0.64 | 1.52 | 1.80 | 0.36 |
| 0.2 (12%) | 5.91 | 0.97 | 2.93 | 4.16 | 0.87 | 2.06 | 3.11 | 0.70 | 1.54 | 2.02 | 0.41 |
| 0.4 (24%) | 7.48 | 1.00 | 3.35 | 5.01 | 0.94 | 2.25 | 3.63 | 0.80 | 1.63 | 2.23 | 0.48 |
| 0.6 (36%) | 10.30 | 1.00 | 4.17 | 6.32 | 0.98 | 2.56 | 4.32 | 0.88 | 1.75 | 2.47 | 0.54 |
Measurement error variance = 67 (40% of the total trait variance). M = the number of repeated measures. The ratio is the ELOD ratio between M measures and 1 measures per subject. Scenario (2): Ten microsatellite markers each with 4 alleles and spaced 10 cM apart; the QTL placed in the middle of the markers.