Table 2.

Cost-effectiveness analysis for 4 repeated measures vs. 1 measure

Measurement error var. (% total var.)	Heritability (% total var.)	Ave ELOD ratio	Sample size savings	CR4,1	CR4,2
11 (10%)	0.20 (18%)	1.17	0.15	16.31	31.20
	0.60 (54%)	1.23	0.19	12.04	26.75
25 (20%)	0.20 (16%)	1.38	0.28	6.83	14.44
	0.60 (48%)	1.51	0.34	4.84	10.41
67 (40%)	0.20 (12%)	2.01	0.50	1.97	4.55
	0.60 (36%)	2.28	0.56	1.34	3.33
150 (60%)	0.20 (8%)	3.07	0.67	0.45	1.33
	0.60 (24%)	3.39	0.71	0.25	0.78

CRm1,m2 is defined in (5). CR4,2 is also listed here for comparison purpose. When Cs/Cp > CRm1,m2, taking m1 measures is better than taking m2 measures per subject. Heritability is defined as (σ²_mg+ σ²_pg)/(σ²_mg+ σ²_pg + σ²_e) where σ²_mg+ σ²_pg + σ²_e= 100 and the major gene effect s²mg is fixed to 20. Average of ELOD ratio is the average across three scenarios that give similar results: (1) a highly informative microsatellite marker with 20 alleles and 0 cM between the marker and the QTL. (2) Ten microsatellite markers each with 4 alleles and spaced 10 cM apart; the QTL placed in the middle of the markers. (3) Fifty SNPs spaced 2 cM apart; the QTL again placed in the middle of the SNPs.