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Fructose metabolism in the liver. Hepatic fructose metabolism begins with phosphorylation of fructokinase. Fructose carbon enters the glycolytic pathway at the triose phosphate level. Thus, fructose bypasses the major control point by which glucose carbon enters glycolysis. This allows fructose to serve as an unregulated source of glycerol-3-phosphate and acetyl-CoA for hepatic lipogenesis.
