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. Author manuscript; available in PMC: 2011 May 27.
Published in final edited form as: J Med Chem. 2010 May 27;53(10):4166–4176. doi: 10.1021/jm1001265

Figure 1.

Figure 1

(A) Structure of compounds 1, 2 and 3. (B) Structure of compound 4 (8r). (C) NMR binding studies. Aliphatic region of the 1H-NMR spectrum of Bcl-XL (15 μM, black) and Bcl-XL in the presence of compound 11 (150 μM, red), 12 (150 μM, green), 13 (150 μM, grey) and 14 (150 μM, blue). (D) Superposition of 2D [15N,1H]-TROSY spectra of free Bcl-XL (200 μM; red) and after addition of compound 11 (200 μM; blue).