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. Author manuscript; available in PMC: 2011 May 27.
Published in final edited form as: J Med Chem. 2010 May 27;53(10):4166–4176. doi: 10.1021/jm1001265

Figure 4.

Figure 4

Mouse embryonic fibroblast cells with wild-type (MEF/WT; dark square) or bax−/−bak−/− double knockout (MEF/DKO, red square) genotypes were treated with compounds 11, 14 and 4 at various concentrations and apoptosis was monitored by Annexin V-FITC assays. (A-C) Compounds 11, 14 and 4. (D) Effects of compounds 11–14 on shrinkage of Bcl-2 mouse spleen at a single intraperitoneal injection dose of 42 mg/kg. All shrinkage data are percentage of maximum reduction of mice spleen size.