Table 2.
Compound | IC50 (μM) FPA | Kd (μM) ITC | |||
---|---|---|---|---|---|
IC50 | Bcl-XL | Bcl-2 | Bfl-1 | Mcl-1 | Bcl-XL |
11 | 0.31 ± 0.05 | 0.32 ± 0.05 | 0.62 ± 0.04 | 0.20 ± 0.02 | 0.1 |
12 | 0.68 ± 0.09 | 1.14 ± 0.09 | 0.59 ± 0.07 | 0.18 ± 0.02 | 2.4 |
13 | 0.44 ± 0.02 | 0.43 ± 0.01 | 0.75 ± 0.07 | 0.24 ± 0.02 | 0.4 |
14 | 0.65 ± 0.06 | 0.43 ± 0.03 | 0.77 ± 0.05 | 0.24 ± 0.02 | 2.0 |
4 | 0.39 ± 0.02 | 0.66 ± 0.02 | 0.42 ± 0.09 | 0.33 ± 0.02 | ND |
ND = Not determined