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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Exp Eye Res. 2009 Dec 29;90(3):444–451. doi: 10.1016/j.exer.2009.12.009

Fig. 2.

Fig. 2

MUC1 expression, cellular protein amount and/or ectodomain release was affected by four of the five inflammatory mediators tested. TNF-α and IFN-γ significantly increased expression and cellular protein by 6 and 24 hours, respectively, followed by ectodomain release at 24 (TNF-α) or 48 hours (IFN-γ). IL-6 decreased cellular MUC1 amount at 1 hour, followed by a decrease in ectodomain release at 6 and 24 hours. IL-17 also decreased the cellular amount of MUC1 at 1 hour, but by 48 hours, there was a significant increase. No significant effects were seen after treatment with IL-8. Combined treatment with TNF-α and IFN-γ or with IL-17 and IFN-γ had no effect over treatment with the cytokines alone.