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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Exp Eye Res. 2009 Dec 29;90(3):444–451. doi: 10.1016/j.exer.2009.12.009

Fig. 3.

Fig. 3

MUC16 cellular protein amount and/or ectodomain release was significantly affected by all five of the inflammatory mediators tested. There was a decrease in ectodomain release after 1 hour of treatment with IL-17. IL-6 increased cellular protein and decreased ectodomain release at 1 hour and decreased both at 24 hours. IL-8 decreased ectodomain release at 24 hours. TNF-α decreased cellular protein at 1 hour and increased ectodomain release at 24 hours. IFN-γ induced the most significant effects, increasing cellular protein at 24 and 48 hours, decreasing ectodomain release at 24 and 48 hours without changes in expression level at 24 hours. By 48 hours, expression levels were significantly upregulated. Combined treatment with TNF-α and IFN-γ or IL-17 and IFN-γ had no effect over treatment with the cytokines alone.