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. Author manuscript; available in PMC: 2010 Jun 4.

Published in final edited form as: Nat Med. 2009 Nov 22;15(12):1377–1382. doi: 10.1038/nm.2062

(a) Quantification of IL-6 and TNF-α mRNA expression of cultured normal human keratinocytes treated with 36 μg ml⁻¹ of a sterile <10 kDa product of S. epidermidis conditioned culture media (SE) and 10 μg ml⁻¹ of the TLR3 ligand [poly(I:C)] for 24 h. (b) Photographs of the ears of BALB/c mice 24 h after subcutaneous injection with PBS alone, SE alone, poly(I:C) alone or SE and poly(I:C). (c) H&E staining of ears treated as in (b), scale bars represent 100 μm. (d) Quantification of IL-6 and TNF-α expression in tissue from mouse ears treated as in (b). **P <0.01 and *** P <0.001. P-values were determined by Two-tailed t tests. All data are representative of three independent experiments with n = 3–6 per group, and are mean ± SEM.

(a) Quantification of IL-6 and TNF-α mRNA expression of cultured normal human keratinocytes treated with 36 μg ml⁻¹ of a sterile <10 kDa product of S. epidermidis conditioned culture media (SE) and 10 μg ml⁻¹ of the TLR3 ligand [poly(I:C)] for 24 h. (b) Photographs of the ears of BALB/c mice 24 h after subcutaneous injection with PBS alone, SE alone, poly(I:C) alone or SE and poly(I:C). (c) H&E staining of ears treated as in (b), scale bars represent 100 μm. (d) Quantification of IL-6 and TNF-α expression in tissue from mouse ears treated as in (b). **P <0.01 and *** P <0.001. P-values were determined by Two-tailed t tests. All data are representative of three independent experiments with n = 3–6 per group, and are mean ± SEM.