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. Author manuscript; available in PMC: 2010 Jun 4.

Published in final edited form as: Nat Med. 2009 Nov 22;15(12):1377–1382. doi: 10.1038/nm.2062

(a) Quantification of IL-6 and TNF-α mRNA expression in skin from C57BL/6 Tlr2-deficient mice and wild-type controls preinjected by PBS or LTA-SA 24 h and 2 h prior to wounding. 2 mm of skin around the wound edges was collected for real-time RT-PCR. (b) H&E staining of skin in Tlr2-deficient mice treated as in (a). The scale bars represent 200 μm. (c) Quantification of IL-6 and TNF-α mRNA expression in skin from C57BL/6 Tlr2-deficient mice stimulated by subcutaneous injection of poly(I:C). Some ears were preinjected with LTA-SA, or PBS 2 h prior to injection of poly(I:C). * P <0.05 and ** P <0.01. n.s. no significance. P-values were evaluated by Two-way ANOVA. Data are the mean ± SEM of n = 5–7 and are representative of three independent experiments.

(a) Quantification of IL-6 and TNF-α mRNA expression in skin from C57BL/6 Tlr2-deficient mice and wild-type controls preinjected by PBS or LTA-SA 24 h and 2 h prior to wounding. 2 mm of skin around the wound edges was collected for real-time RT-PCR. (b) H&E staining of skin in Tlr2-deficient mice treated as in (a). The scale bars represent 200 μm. (c) Quantification of IL-6 and TNF-α mRNA expression in skin from C57BL/6 Tlr2-deficient mice stimulated by subcutaneous injection of poly(I:C). Some ears were preinjected with LTA-SA, or PBS 2 h prior to injection of poly(I:C). * P <0.05 and ** P <0.01. n.s. no significance. P-values were evaluated by Two-way ANOVA. Data are the mean ± SEM of n = 5–7 and are representative of three independent experiments.