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. Author manuscript; available in PMC: 2011 May 25.
Published in final edited form as: J Am Coll Cardiol. 2010 May 25;55(21):2319–2327. doi: 10.1016/j.jacc.2010.02.029

Table 2.

Hazard Ratios for Risk of Incident AF in Relation to Body Mass Index

<25 kg/m2 25–30 kg/m2 ≥ 30kg/m2 Continuous BMI
ALL ATRIAL FIBRILLATION EVENTS INCLUDED
N participants (%) 17544 (51.1) 10580 (30.8) 6185 (18.0) 34309
Number of events (%) 344 (2.0) 259 (2.5) 231 (3.7) 834 (2.4)
Age-adjusted incidence/1000 py 1.55 1.85 2.98 1.90+
Relative risks (Baseline examination)
Age-adjusted (n=34309)* Referent 1.19 (1.01, 1.40) 2.06 (1.74, 2.43) 1.06 (1.05, 1.07)
Multivariable adjusted I (n=33990)** Referent 1.13 (0.96, 1.34) 1.77 (1.47, 2.11) 1.05 (1.03, 1.06)
Relative risks (Variables updated)
Age-adjusted (n=34309)* Referent 1.28 (1.09, 1.52) 1.98(1.67–2.36) 1.06 (1.05, 1.07)
Multivariable adjusted I (n=34045)** Referent 1.22 (1.02, 1.45) 1.65 (1.36, 2.00) 1.04 (1.03, 1.06)
WOMEN CENSORED AT THE FIRST CARDIOVASCULAR EVENT
Number of events (%) 331 (1.9) 233 (2.2) 214(3.5) 778 (2.3)
Age-adjusted incidence/1000 py 1.49 1.67 2.76 1.77+
Relative risks (Baseline)
Age-adjusted (n=34309)* Referent 1.11(0.94–1.32) 1.98 (1.66, 2.35) 1.06 (1.05, 1.07)
Multivariable adjusted I (n=33990) ** Referent 1.07(0.90–1.27) 1.75(1.45–2.11) 1.05 (1.03, 1.06)
WOMEN IN THE BIOMARKER COHORT
N participants (%) 12774 (51.9) 7528 (30.6) 4319 (17.5) 24621
Number of events (%) 268 (2.1) 211 (2.8) 167 (3.9) 646 (2.6)
Age-adjusted incidence/1000 py 1.66 2.13 3.05 2.05+
Relative risks (Baseline)
Age-adjusted (n=24621) * Referent 1.27 (1.06, 1.53) 1.97 (1.62, 2.39) 1.06 (1.04, 1.07)
Multivariable adjusted I (n=24394) ** Referent 1.20 (1.00, 1.45) 1.68 (1.37, 2.07) 1.04 (1.03, 1.06)
Multivariable adjusted II (n=24203) *** Referent 1.15 (0.95, 1.39) 1.53 (1.22, 1.91) 1.04 (1.02, 1.05)
*

adjusted for age, vitamin E, beta carotene, and aspirin use

**

adjusted for age, race, vitamin E, beta carotene, aspirin use, diabetes, hypertension (defined as self-reported systolic blood pressure of ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg, or report of diagnosis of hypertension by a physician), history of hypercholesterolemia (self-reported cholesterol of at least 240 mg/dl (6.22 mmol/l)), diabetes, alcohol consumption (rarely/never, <1 drink per week, 1 to 6 drinks per week, ≥1 drink per day), smoking (never, past, current), and physical activity ( < 1000 kilocalories per week, ≥1000 kilocalories per week)

***

adjusted for clinical variables above, and log-transformed hsCRP, ICAM and fibrinogen levels

+

this number reflects the overall age-adjusted incidence rate for the entire cohort