Table 2.
Hazard Ratios for Risk of Incident AF in Relation to Body Mass Index
| <25 kg/m2 | 25–30 kg/m2 | ≥ 30kg/m2 | Continuous BMI | |
|---|---|---|---|---|
| ALL ATRIAL FIBRILLATION EVENTS INCLUDED | ||||
| N participants (%) | 17544 (51.1) | 10580 (30.8) | 6185 (18.0) | 34309 |
| Number of events (%) | 344 (2.0) | 259 (2.5) | 231 (3.7) | 834 (2.4) |
| Age-adjusted incidence/1000 py | 1.55 | 1.85 | 2.98 | 1.90+ |
| Relative risks (Baseline examination) | ||||
| Age-adjusted (n=34309)* | Referent | 1.19 (1.01, 1.40) | 2.06 (1.74, 2.43) | 1.06 (1.05, 1.07) |
| Multivariable adjusted I (n=33990)** | Referent | 1.13 (0.96, 1.34) | 1.77 (1.47, 2.11) | 1.05 (1.03, 1.06) |
| Relative risks (Variables updated) | ||||
| Age-adjusted (n=34309)* | Referent | 1.28 (1.09, 1.52) | 1.98(1.67–2.36) | 1.06 (1.05, 1.07) |
| Multivariable adjusted I (n=34045)** | Referent | 1.22 (1.02, 1.45) | 1.65 (1.36, 2.00) | 1.04 (1.03, 1.06) |
| WOMEN CENSORED AT THE FIRST CARDIOVASCULAR EVENT | ||||
| Number of events (%) | 331 (1.9) | 233 (2.2) | 214(3.5) | 778 (2.3) |
| Age-adjusted incidence/1000 py | 1.49 | 1.67 | 2.76 | 1.77+ |
| Relative risks (Baseline) | ||||
| Age-adjusted (n=34309)* | Referent | 1.11(0.94–1.32) | 1.98 (1.66, 2.35) | 1.06 (1.05, 1.07) |
| Multivariable adjusted I (n=33990) ** | Referent | 1.07(0.90–1.27) | 1.75(1.45–2.11) | 1.05 (1.03, 1.06) |
| WOMEN IN THE BIOMARKER COHORT | ||||
| N participants (%) | 12774 (51.9) | 7528 (30.6) | 4319 (17.5) | 24621 |
| Number of events (%) | 268 (2.1) | 211 (2.8) | 167 (3.9) | 646 (2.6) |
| Age-adjusted incidence/1000 py | 1.66 | 2.13 | 3.05 | 2.05+ |
| Relative risks (Baseline) | ||||
| Age-adjusted (n=24621) * | Referent | 1.27 (1.06, 1.53) | 1.97 (1.62, 2.39) | 1.06 (1.04, 1.07) |
| Multivariable adjusted I (n=24394) ** | Referent | 1.20 (1.00, 1.45) | 1.68 (1.37, 2.07) | 1.04 (1.03, 1.06) |
| Multivariable adjusted II (n=24203) *** | Referent | 1.15 (0.95, 1.39) | 1.53 (1.22, 1.91) | 1.04 (1.02, 1.05) |
adjusted for age, vitamin E, beta carotene, and aspirin use
adjusted for age, race, vitamin E, beta carotene, aspirin use, diabetes, hypertension (defined as self-reported systolic blood pressure of ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg, or report of diagnosis of hypertension by a physician), history of hypercholesterolemia (self-reported cholesterol of at least 240 mg/dl (6.22 mmol/l)), diabetes, alcohol consumption (rarely/never, <1 drink per week, 1 to 6 drinks per week, ≥1 drink per day), smoking (never, past, current), and physical activity ( < 1000 kilocalories per week, ≥1000 kilocalories per week)
adjusted for clinical variables above, and log-transformed hsCRP, ICAM and fibrinogen levels
this number reflects the overall age-adjusted incidence rate for the entire cohort