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. Author manuscript; available in PMC: 2011 Mar 25.
Published in final edited form as: J Med Chem. 2010 Mar 25;53(6):2562–2576. doi: 10.1021/jm9018542

Figure 2.

Figure 2

Chronic infusion of compound 4 resulted in improved echocardiographically derived FS in CSQ heart failure mice. Following chronic subcutaneous infusion of NS or compound 4, two-dimensional directed M-mode echocardiography was carried out as described in Methods. The heart rate (HR) is indicated on each figure. Representative M-mode echocardiography was shown for a CSQ animal infused with NS (A) and for a CSQ mouse infused with compound 4 (B). A heart from the NS-infused mice showed less shortening of both septum and LV free wall than did compound 4-infused mice.