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. Author manuscript; available in PMC: 2011 Mar 25.
Published in final edited form as: J Med Chem. 2010 Mar 25;53(6):2562–2576. doi: 10.1021/jm9018542

Scheme 3.

Scheme 3

Reagents and Conditions. a) Dess-Martin periodinane, an. CH2Cl2, 80%; b) Tetraisopropyl methylenediphosphonate, NaH, an. THF, 83%; c) 2 M NH3 in i-PrOH, 70 °C, 80%; d) 10% Pd/C, H2 (3 bar), MeOH:2M aq. NaOH (1:1, v/v), 79%; e) Iodotrimethylsilane, an. CH2Cl2, 47% for 10 and 28% for 7.