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. Author manuscript; available in PMC: 2011 Mar 25.
Published in final edited form as: J Med Chem. 2010 Mar 25;53(6):2562–2576. doi: 10.1021/jm9018542

Scheme 5.

Scheme 5

Reagents and Conditions. a) 10% Pd/C, H2 (3 bar), MeOH, 72%; b) Triphenylphosphine, 2,6-dichloropurine, diisopropyl azodicarboxylate, an. THF, 40%; c) 2 M NH3 in i-PrOH, 70 °C, 71%; d) Iodotrimethylsilane, an. CH2Cl2, 45% combined yield.