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. Author manuscript; available in PMC: 2011 Mar 25.
Published in final edited form as: J Med Chem. 2010 Mar 25;53(6):2562–2576. doi: 10.1021/jm9018542

Scheme 6.

Scheme 6

Reagents and Conditions. a) CBr4, triphenylphosphine, triethylamine, 81%; b) Diethylmethylphosphite, 110 °C, 95%; c) TBAF, THF, 91%, d) Triphenylphosphine, 2,6-dichloropurine, diisopropyl azodicarboxylate, an. THF, 75%; e) 2 M NH3 in i-PrOH, 70 °C, 60%; f) Iodotrimethylsilane, an. CH2Cl2, 20% combined yield.