. Author manuscript; available in PMC: 2011 Mar 25.

Published in final edited form as: J Med Chem. 2010 Mar 25;53(6):2562–2576. doi: 10.1021/jm9018542

Table 1.

Phosphonate analogues: structure and effects on in vivo heart function as determined by echocardiography-derived FS in CSQ heart failure mice.

No	FS in % in CSQ Mice^a	n =
3	15.47 ± 1.15	10
4	20.25 ±1.19	8
5	16.23 ± 0.93	13
7	12.12 ±1.2	11
8	13.88 ± 2.12	8
9	19.26 ± 1.23	16
10	11.15 ±1.44	12
11	15.0 ± 1.2	10
12	ND

at 3.3 µM. The vehicle control mice displayed a %FS of 13.78 ± 1.19% (n=16).

ND – not determined.