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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Cancer Res. 2009 Nov 24;69(23):8839–8843. doi: 10.1158/0008-5472.CAN-09-1970

Table 1.

Myc regulates the expression of target genes involved in ribosome biogenesis and protein synthesis

Myc Target Genes Function
Ribosomal Proteins: (Large and Small subunit). i.e.
RPL21; RPL23A; RPL29; RPL34; RPL35; RPL39;
RPS14; RPS16; RPS17; RPS19; RPS24; RPS25;
RPS3		 Structural components of the ribosome and protein synthesis
control.
Translation factors: Initiation factors, eIF4E, eIF4G,
eIF4A, eIF4B, eIF5A. Elongation factors, EEF1B2;
EEF1D; EEF1G.		 Proteins that regulate the initiation or elongation steps
of protein synthesis.
Nucleophosmin (NPM) Ribosome biogenesis
Upstream Binding Factor (UBF) rRNA transcription
DKC1 rRNA modifications. Component of the H/ACA-box snoRNPs.
Control of IRES-dependent translation.
Nucleolar antigen Nop52 pre-rRNA processing
Nucleolar protein Nop56 rRNA modifications. Component of the C/D-box snoRNPs
Ribosomal RNA (rRNA) Structural components of the ribosome