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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Pharmacol Res. 2009 Oct 17;61(1):14–26. doi: 10.1016/j.phrs.2009.10.002

Figure 3. Directing neurotrophic factors to the region of diseased neurons.

Figure 3

The tissue location of NTF production by a viral vector is determined by NTF receptor expression on diseased neurons (cell body versus processes) and tropism of the viral vector being used. Vectors can be delivered to the cell body (A-left) or neuritic processes (A-right) of the diseased neurons. (B) Viral vector targeting to the region of the neuron body can directly transduce the diseased neuron, glia or other neurons for secretion of the therapeutic NTF. (C) Viral vector placed in the region of the neuritic processes of the target neuron can lead to retrograde delivery of the vector genome to the nucleus of the target neuron (dashed line) or transduce glia or cells innervated by the diseased neuron to secrete the therapeutic NTF.