Table 3.

Peak and last detectable concentrations, and elimination half-life after a single 10 mg/kg IV dosage of Ab-01 or Ab-02 to cynomolgus monkeys

Group	Animal	Cpeak (μg/mL)	t1/2 (days)	Clast (μg/mL)	Tlast (days)
A (Ab-01)	1	200	12	0.91	50
	2	139	6.2	0.56	36
	3	153	14	0.37	71
	Mean	164	11	0.61	52
	SD	32	3.9	0.27	18
B (Ab-02)	4	145	2.5	0.36	15
	5	155	2.3	0.26	15
	6	201	2.1	0.25	15
	Mean	167	2.3	0.29	15
	SD	30	0.16	0.06	0

C_peak = Concentration at 5 minutes, the first sampling time point after IV administration; t_1/2 = elimination half-life; T_last = last time point at which the test article concentration was above the LOQ (30.0 ng/mL); C_last = concentration at T_last.