Table 4.
TIME (DAYS) |
ANIMAL 4 | ANIMAL 5 | ANIMAL 6 |
---|---|---|---|
Pre-dose | Negative | Negative | Negative |
15 | Negative | Negative | Negative |
22 | 4.12 | 2.7 | 2.2 |
36 | 2.2 | 2.7 | 2.7 |
Formation of neutralizing anti-Ab-02 was assessed using a flow cytometric assay, in which serum samples from Ab-02 dosed monkeys were tested for inhibition (relative to pre-dose) of anti-IL-21R-biotin binding to TF-1 cells transfected with human IL-21R. Negative samples had no inhibition at the minimum required dilution of 1:6 and had a log titer < 0.78.