Table 5.
Associations of total antioxidant index and macronutrients with glioma survival†, stratified by histology group
| Nutrient (unit) Tertiles | All or self-report (SR) only | Grade II | Grade III | Grade IV | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Lower limit | Upper limit | (143 cases, 72 deaths) | (130 cases, 103 deaths) | (475 cases, 473 deaths) | ||||||
| HR | 95% CI | HR | 95% CI | HR | 95% CI | |||||
| Antioxidant index | ||||||||||
| T1: | 50.1 | to | 1961.9 | ALL | 1 | 1 | 1 | |||
| T2: | 1963.2 | to | 3263.0 | 1.34 | (0.70-2.54) | 1.31 | (0.78-2.18) | 1.02 | (0.78-1.32) | |
| T3: | 3266.1 | to | 13512.6 | 0.67 | (0.30-1.47) | 1.04 | (0.58-1.88) | 0.36* | (1.02-1.81) | |
| T1: | 50.1 | to | 1961.9 | SR | 1 | 1 | 1 | |||
| T2: | 1963.2 | to | 3263.0 | 1.41 | (0.71-2.80) | 1.36 | (0.62-2.94) | 1.18 | (0.82-1.68) | |
| T3: | 3266.1 | to | 13512.6 | 0.74 | (0.31-1.77) | 1.03 | (0.49-2.16) | 1.07 | (0.72-1.59) | |
| Total Protein (g) | ||||||||||
| T1: | 11.4 | to | 49.5 | ALL | 1 | 1 | 1 | |||
| T2: | 49.6 | to | 70.8 | 0.44* | (0.20-0.95) | 1.44 | (0.75-2.74) | 1.08 | (0.83-1.40) | |
| T3: | 71.1 | to | 241.5 | 0.32 | (0.10-1.04) | 1.73 | (0.78-3.83) | 0.64* | (0.43-0.95) | |
| T1: | 11.4 | to | 49.5 | SR | 1 | 1 | 1 | |||
| T2: | 49.6 | to | 70.8 | 0.40* | (0.18-0.93) | 1.57 | (0.74-3.31) | 1.13 | (0.78-1.62) | |
| T3: | 71.1 | to | 241.5 | 0.53 | (0.15-1.81) | 1.18 | (0.42-3.27) | 0.88 | (0.52-1.50) | |
| Total Fat (g) | ||||||||||
| T1: | 10.2 | to | 47.1 | ALL | 1 | 1 | 1 | |||
| T2: | 47.2 | to | 72.7 | 1.33 | (0.60-2.96) | 0.77 | (0.43-1.38) | 1.13 | (0.87-1.47) | |
| T3: | 72.9 | to | 213.0 | 0.88 | (0.29-2.66) | 0.73 | (0.35-1.51) | 1.10 | (0.74-1.63) | |
| T1: | 10.2 | to | 47.1 | SR | 1 | 1 | 1 | |||
| T2: | 47.2 | to | 72.7 | 1.10 | (0.47-2.54) | 0.67 | (0.29-1.53) | 1.06 | (0.73-1.53) | |
| T3: | 72.9 | to | 213.0 | 0.81 | (0.26-2.53) | 0.74 | (0.30-1.85) | 1.11 | (0.61-2.01) | |
| Total Cholesterol (mg) | ||||||||||
| T1: | 17.2 | to | 166.1 | ALL | 1 | 1 | 1 | |||
| T2: | 166.2 | to | 272.7 | 0.53 | (0.24-1.14) | 0.86 | (0.49-1.49) | 1.50* | (1.17-1.93) | |
| T3: | 273.0 | to | 1322.0 | 0.76 | (0.31-1.86) | 0.49* | (0.25-0.95) | 1.31 | (0.97-1.78) | |
| T1: | 17.2 | to | 166.1 | SR | 1 | 1 | 1 | |||
| T2: | 166.2 | to | 272.7 | 0.59 | (0.25-1.41) | 1.04 | (0.53-2.03) | 1.39 | (0.98-1.97) | |
| T3: | 273.0 | to | 1322.0 | 1.00 | (0.38-2.59) | 0.68 | (0.28-1.63) | 1.13 | (0.71-1.80) | |
† adjusted for reporting status (all cases vs self reported cases only), age at diagnosis (<48,48-65,>65), treatment (radiation, chemo, surgery - yes/no), education (<12, 12, >12), marital status (yes/no), total calories (continuous), pack years (median = 18.5), and age at first alcoholic drink (<18,18-20,>20).
* p < 0.05