Table 2.
The parameters of predicted helical tomotherapy plan within mean 30 Gy to normal liver of hepatocellular carcinoma compared with selected published series.
| Published series | Modality | Mean Tumor dose (Gy) /fraction size (Gy) |
V30 (%) | Suggested mean dose (Gy) of normal liver under radiotherapy |
|---|---|---|---|---|
| Dawson et al. [28] | 3DCRT | 52.5/1.5-1.65 | 30 Gy10 | |
| Kim et al. [29] | 3DCRT | 54/2 | 30 Gy | |
| Cheng et al. [45] | 3DCRT | 50/1.8-2 | 42% | |
| Liang et al. [40] | 3DCRT | 50/4-6 | 35% | 28 Gy10 |
| Yamada et al. [44] | 3DCRT | 57/2 | 40% | |
| IMRT | Coplanar IMRT | 50.4/1.8 | 21% | 20 Gy |
| IMRT | Noncoplanar IMRT | 50.4/1.8 | 17% | 20 Gy |
| HT | Tomotherapy | 50.4/1.8 | 17% | 20 Gy |
Abbreviations: 3DCRT = Three-dimensional conformal radiotherapy; HT = Helical tomotherapy; V30 = percent volume of normal liver with radiation dose more than 30 Gy; X Gy10 = a biologic effective dose (BED) of X Gy10 as the α/β ratio = 10 in daily fraction of 2 Gy; OARs = Organs at risk.