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Cold Intolerance Symptom Severity (CISS) score in subgroups. The cut-off for abnormality is based on the 95th percentile of the highest CISS scores in the normal population [6]). An abnormal CISS score was seen in 39/86 (45%) patients with a traumatic hand injury and in 21/28 (75%) of patients with HAVS. Patients with HAVS had significantly higher CISS scores than patients with traumatic hand injury (p = 0.004).
