Figure 6.

Overlap of functional terms between rat strains/lines. Gene Ontology (GO) analysis was used to determine if different combinations of strains/lines led to alterations in mRNA levels for functionally coherent groups of genes. The gene-lists for each of the four strains/lines were tested for enrichment of each GO category represented on the RAE230A array. False-discovery rates were calculated with 1000 permutations of the dataset using the High-Throughput GoMiner software and a threshold of 5% FDR was applied. The vast majority of GO terms enriched in both the resistant (A) and the sensitive (B) strains/lines overlap. A four-way overlap of all strains/lines shows significant overlap, but also some strain-specific responses (C).