Table 2.
Known dioxin-inducible genes
| Resistant Collective | Sensitive Collective | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| H/W | LnA | L-E | LnC | |||||||
| FC log2 | padj | FC log2 | padj | FC log2 | padj | FC log2 | padj | Gene ID | Symbol | Full Name |
| 6.3 | 3.2 × 10-9 | 5.4 | 8.2 × 10-8 | 6.8 | 2.2 × 10-12 | 6.2 | 8.9 × 10-10 | 25375 | Aldh3a1 | aldehyde dehydrogenase 3 family, member A1 |
| 6.4 | 1.3 × 10-4 | 6.1 | 1.0 × 10-6 | 6.6 | 3.3 × 10-8 | 6.4 | 1.8 × 10-9 | 24296 | Cyp1a1 | cytochrome P450, family 1, subfamily a, polypeptide 1 |
| 1.2 | 2.0 × 10-5 | 1.2 | 1.6 × 10-5 | 1.1 | 1.5 × 10-6 | 1.1 | 1.9 × 10-5 | 24297 | Cyp1a2 | cytochrome P450, family 1, subfamily a, polypeptide 2 |
| 3.9 | 6.8 × 10-5 | 3.5 | 4.9 × 10-7 | 5.3 | 4.4 × 10-6 | 4.9 | 7.8 × 10-6 | 25426 | Cyp1b1 | cytochrome P450, family 1, subfamily b, polypeptide 1 |
| 1.2 | 4.4 × 10-3 | 1.1 | 1.9 × 10-3 | 1.9 | 3.8 × 10-4 | 1.4 | 1.9 × 10-3 | 83619 | Nfe2l2 | nuclear factor, erythroid derived 2, like 2 |
| 3.7 | 3.2 × 10-5 | 2.5 | 1.4 × 10-4 | 2.4 | 4.9 × 10-5 | 2.6 | 4.5 × 10-5 | 24314 | Nqo1 | NAD(P)H dehydrogenase, quinone 1 |
| 2.3 | 1.2 × 10-3 | 1.8 | 1.3 × 10-3 | 2.5 | 1.6 × 10-4 | 2.2 | 1.7 × 10-4 | 310467 | Tiparp | TCDD-inducible poly(ADP-ribose) polymerase |
Transcriptional responses after 19-hour TCDD exposure in the four rat strains/lines were identified using Affymetrix RAE230A arrays followed by data pre-processing and statistical testing using linear models. Twenty-five Type-I genes (similar response to TCDD in all four strains/lines) were identified. These included several well-established AHR-regulated and dioxin-inducible genes, supporting the validity of the array experiments. For each strain/line, the fold-change (FC in log2 space) in mRNA levels between treated and control rats as well as the significance levels are presented.