. Author manuscript; available in PMC: 2010 Aug 13.

Published in final edited form as: J Pharmacokinet Pharmacodyn. 2009 Aug 13;36(4):367–379. doi: 10.1007/s10928-009-9127-7

Table 2.

Summary of RMSE for parameter estimates and standard error estimates for all parameters and all models.

Poisson model
	λ			Ω(λ)
RMSE(parameter)	5.23			8.56
RMSE (standard error)	0.26			0.66
Poisson model with Markov element
	λ1	λ2	Ω(λ1)	Ω(λ2)	Cov(λ₁–λ₂)
RMSE(parameter)	4.23	3.91	7.60	8.68	7.91
RMSE (standard error)	0.23	0.20	0.46	0.52	0.64
Poisson model with mixtures in individual observations
	λ1	λ2		MP	Ω(λ1)
RMSE(parameter)	4.97	2.47		0.79	7.14
RMSE (standard error)	0.24	0.05		0.02	0.47
Zero inflated Poisson model
	λ1	P0		Ω(λ1)	Ω(P0)
RMSE(parameter)	4.35	7.85		8.07	10.81
RMSE (standard error)	0.23	0.36		0.62	1.22
Generalized Poisson model
	λ1	δ		Ω(λ1)	Ω(δ)
RMSE(parameter)	3.98	8.05		6.87	13.13
RMSE (standard error)	0.20	0.36		0.44	1.54
Negative binomial model
	λ1	Ovdp		Ω(λ1)	Ω(Ovdp)
RMSE(parameter)	4.24	12.34		7.29	11.28
RMSE (standard error)	0.22	1.00		0.47	1.43