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The kinetic analysis of α-Syn variants in this study.
| Lag-time (h) | Full-length α-Syn | α-Syn110 | α-Syn119 | α-Syn133 |
|---|---|---|---|---|
| α-Syn (70 μM) | 21.4 | 4.8 | 14.3 | 36.1 |
|
Truncated α-Syn (35 μM) + Full-length α-Syn (35 μM) |
- | 5.0 | 8.8 | 31.4 |
|
α-Syn (70 μM) + PQQ (280 μM) |
30.5 | 8.6 | 23.5 | 47.7 |
The lag time analysis of fibril formation was calculated from fitting-curve of TfT fluorescence was provided by PRISM (GraphPad Software)
