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. 2010 May 18;10:46. doi: 10.1186/1471-230X-10-46

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Copyright ©2010 Miura et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Early detection of small HCC by circulating hTERT mRNA and immunohistochemical analysis of HCC tissues. (a) Imaging diagnosis regarding case with 6 mm HCC. A. Ultrasonography and B. computed tomography of the smallest HCC detected by hTERTmRNA. The diameter of HCC was 6 mm. Left, ultrasonography; right, CT (b) Immunohistochemical analysis of HCC tissues. A. Ki-67 staining (×400), B. hTERT staining (×400), C. TUNEL (×400), D. Labeling indices of Ki-67, hTERT and TUNEL in regard to differential degree of HCC.