Table 6.
Genes coding for transcription factors displaying altered expression in LP-1 derivatives.
| Gene | Protein | LP-1D1b vs. cl1 | LP-1K vs. cl1 |
|---|---|---|---|
| DDIT3 | DNA-damage-inducible transcript 3 | +3.34* | nm** |
| ATF3 | Activating transcription factor 3 | +2.27 | nm |
| XBP1 | X-box binding protein 1 | +2.24 | nm |
| IRF8 | Interferon regulatory factor 8 | +2.21 | nm |
| RUNX1 | Runt-related transcription factor 1 | nm | +5.13 |
| TCF4 | Transcription factor 4 | nm | +4.40 |
| MITF | Microphtalmia-associated transcription factor | nm | +3.50 |
| NOTCH2 | Notch homolog 2 | nm | +3.36 |
| STAT5A | Signal transduction and transcription factor 5A | nm | +2.49 |
| ETV6 | Ets variant 6 | nm | +2.32 |
| MAF | v-maf musculoaponeurotic fibrosarcomaa oncogene homolog | nm | +2.25 |
| MYC | v-myc myelocytomatosis viral oncogene homolog | nm | +2.08 |
| ETS2 | v-ets erythroblastosis virus E26 oncogene homolog | nm | +2.06 |
| IRF4 | Interferon regulated factor 4 | nm | -2.25 |
| RBPJ | Recombination signal binding protein for Ig kappa region | nm | -2.38 |
| REL | v-rel reticuloendotheliosis viral onvogene homolog | nm | -3.63 |
| RUNX2 | Runt-related transcription factor related 2 | nm | -4.80 |
| MYBL2 | v-myb myeloblastosis viral oncogene homolog-like 2 | nm | -5.18 |
| ATF4 | Activating transcription factor 4 | +2.75 | +2.64 |
*, ** see legend of table 2. Since minor alterations in the level of transcription factors could have dramatic effects on gene expression, we sorted genes with a |FC|>2. Only genes coding for transcription factors recognized in the literature as relevant for myeloma pathogenesis are indicated.