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miR-215 reduces the chemosensitivity to DHFR inhibitor MTX (A) or TS inhibitor TDX (B) in the HCT 116 (wt-p53) cells via targeting DTL (C and D). HCT 116 (wt-p53) cells transfected with miR-215 or siRNAs specific for DHFR, TS or DTL were incubated with MTX or TDX ranged from 10-200 nM for 72 h, and WST-1 assays were performed. siRNAs specific against DHFR, TS or DTL were positive controls.
