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Ubiquitin ligases that interact with Ubc13 are necessary for the rapid degradation of α1. Measurement of the α13HA degradation rate at 30° is shown in wild-type, dma1Δ, dma2Δ, and dma1Δ dma2Δ cells. A representative experiment is shown at the top, and the quantitative results of multiple experiments are shown below.
