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. 2010 Jun;185(2):573–585. doi: 10.1534/genetics.110.116293

Figure 4.—

Figure 4.—

UNC-18 functions cell nonautonomously in neurons to regulate the Venus∷UNC-6 localization in muscle. Venus∷UNC-6 in a worm expressing muscle-specific UNC-18 (A) or neuron-specific UNC-18 (B). YC84[unc-18(e234); ghIs9(Venus∷unc-6); ghEx20(myo-3p∷unc-18∷mCherry; myo-2p∷mRFP)] worms were used for the muscle-specific expression, and YC85[unc-18(e234); ghIs9(Venus∷unc-6); ghEx21(H20p∷unc-18∷mCherry; myo-2p∷mRFP)] worms were used for the neuron-specific expression. Arrowheads indicate the accumulated Venus∷UNC-6 in muscle cells. Arrows indicate the myo-2p∷mRFP fluorescence used as an expression marker. Anterior is to the right. Bar, 20 μm. The accumulation of Venus∷UNC-6 was observed in worms expressing muscle-specific UNC-18 (A), but little accumulation of Venus∷UNC-6 was observed with the neuron-specific expression (B).