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. 2010 Jun;185(2):655–670. doi: 10.1534/genetics.110.115774

TABLE 2.

True QTL location in centimorgans (cM) as well as posterior means and standard deviations of δ, μ, a, and σe2 obtained by the exact and two-step approaches for selected replicates of the simulation with 1500 effective individuals in the base population and a heritability of 0.05

Method Replicate True δ, cM Inline graphic, cM Inline graphica Inline graphicb Inline graphicc
Exact 1 0.60 0.62 (±0.05) 0.00 (±0.09) 0.43 (±0.10) 0.91 (±0.07)
2 0.42 0.44 (±0.24) 0.03 (±0.10) 0.21 (±0.12) 1.02 (±0.09)
3 0.25 0.35 (±0.09) −0.08 (±0.11) 0.37 (±0.12) 0.94 (±0.08)
4 0.59 0.54 (±0.26) 0.00 (±0.11) 0.20 (±0.12) 1.03 (±0.09)
5 0.38 0.39 (±0.22) 0.03 (±0.12) 0.28 (±0.15) 1.04 (±0.09)
6 0.52 0.48 (±0.17) 0.06 (±0.13) 0.29 (±0.15) 1.08 (±0.09)
Two-step 1 0.60 0.66 (±0.04) −0.02 (±0.10) 0.42 (±0.12) 0.91 (±0.07)
2 0.42 0.51 (±0.29) 0.03 (±0.10) 0.20 (±0.11) 1.01 (±0.08)
3 0.25 0.35 (±0.07) −0.07 (±0.11) 0.37 (±0.15) 0.93 (±0.08)
4 0.59 0.56 (±0.23) 0.00 (±0.10) 0.21 (±0.12) 1.02 (±0.09)
5 0.38 0.52 (±0.19) 0.02 (±0.10) 0.24 (±0.14) 1.03 (±0.09)
6 0.52 0.43 (±0.23) 0.04 (±0.11) 0.23 (±0.13) 1.07 (±0.09)
a

μ = 0.

b

a = 0.324.

c

Inline graphic.