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. Author manuscript; available in PMC: 2010 Jun 5.
Published in final edited form as: J Struct Funct Genomics. 2010 Apr 11;11(1):51–59. doi: 10.1007/s10969-010-9086-7

Figure 1.

Figure 1

Flowchart of the SkyLine pipeline. SkyLine [6] starts with a single PDB structure as input. The sequence of the structure is used as a seed in PSI-BLAST profile searches for homologs. Models are built for all non-redundant sequences detected using the input structure as the template and the sequence alignments derived from the PSI-BLAST profiles. Structure evaluation programs discern the reliable models, which comprise family members associated with the input structure. The models and associated information are stored in SkyBase, a web-accessible database.