Figure 2.
Overall scheme of the computational structure-based characterization of protein families. START domain sequences and there models, calculated in the SkyLine analysis of a protein structure (PDB id 1LN1, [27]) are retrieved according to a variety of search parameters, including sequence and modeling features. Each model can be manipulated and visualized in a Jmol window, side-by-side with its Verify3D evaluation profile [37]. Links to MarkUs [13] provide access to previously calculated annotation results and the opportunity for further function analysis.
