Table 2.
Gene Variants Associated With Incident Ischemic Stroke in White Participants of CHS
| Gene | dbSNP ID | Risk Allele* | Allele Frequency† | HR‡ (90% CI) | P |
|---|---|---|---|---|---|
| HPS1 | rs1804689 | T | 0.30 | 1.23 (1.09–1.40) | 0.003 |
| ITGAE | rs220479 | C | 0.82 | 1.26 (1.08–1.48) | 0.008 |
| ABCG2 | rs2231137 | C | 0.95 | 1.46 (1.05–2.03) | 0.03 |
| MYH15 | rs3900940 | C | 0.29 | 1.15 (1.02–1.31) | 0.03 |
| FSTL4 | rs13183672 | A | 0.76 | 1.17 (1.01–1.35) | 0.04 |
| CALM1 | rs3814843 | G | 0.05 | 1.31 (1.02–1.68) | 0.04 |
| BAT2 | rs11538264 | G | 0.97 | 1.49 (1.02–2.16) | 0.04 |
*
Risk allele was defined to be the CHD risk allele as described in Supplemental Table 1 in reference 6.
†
Frequency of the risk allele in white participants of CHS.
‡
Hazard ratios (HRs) are adjusted for baseline age, sex, body mass index, current smoking, diabetes, impaired fasting glucose, hypertension, LDL cholesterol, and HDL cholesterol at baseline. HRs are per copy of the risk allele.