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Suppression of sclerostin under hypoxia occurs in osteogenic cells and involves MEF2 transcription factors. A: Sost expression was analyzed in total RNA from osteoblasts, osteocytes, and embryonic kidney cells cultured under 21% or 1% oxygen. Bars represent mean transcript expression relative to 21% oxygen cultures±SEM. B: Mef2-luciferase activity is decreased under 1% oxygen culture compared to 21% culture in UMR 106.01 cells. *P<0.05 compared to control or vehicle-treated cells.
