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HIF-α stabilization mimics the effect of hypoxia upon transcription of Sost and BMP antagonists. UMR106.01 cells cultured at 21% oxygen in the presence of the HIF-α stabilizing agent DFO (50 or 100 µM) for 48 h reveal decreased Sost transcription and increased Grem 1 and Noggin expression relative to control cultures. Bars represent mean transcript level ± SEM normalized to 21% oxygen, n = 3 per condition.*P<0.05 compared to control; **P<0.01 compared to control.
