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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Neurobiol Learn Mem. 2010 Apr 11;94(1):57–64. doi: 10.1016/j.nlm.2010.04.001

Figure 3. Water maze performance depends on neonatal treatment and age.

Figure 3

Rats were treated on P4 with PBS or E. coli, and tested for spatial learning & memory at 2 month or 16 month of age using a hidden platform task. Rats infected as neonates acquired the task faster than PBS controls at 2 months (A) but not at 16 months (B) of age. (C) Performance during the probe trials: Difference score = time in the platform quadrant minus time in the next best quadrant for each rat, indicative of selective searching in the target platform; *significantly different from PBS at the same time point, p<0.05.