Table 1.
List of Oncolytic viruses delivering angiostatic gene therapy
| OV Name | Virus Type | Therapeutic gene | In Vivo Cancer Model | Reference | |
|---|---|---|---|---|---|
| 1 | ZD55-VEGI-251 | Ad | VEGI 251 | Cervical, Colorectal | Xiao T et al. Cell Research 2009; doi: 10.1038/cr.2009.126 |
| 2 | GLV-1h68 | VV | GLAF-1 | Pancreatic Carcinoma, Prostate Carcinoma | Frentzen et al. Proc Natl Acad Sci USA 2009;106:12915–12920 |
| 3 | ZD55-sflt-1 | Ad | sFlt-1 | Colorectal | Zhang Z et al. Mol Ther 2005;11:553–62 |
| 4 | Vvdd- VEGFR-1-Ig | VV | sFlt-1 | Renal Cell Cancer | Guse K et al. J Virol 2010;84:856–866 |
| 5 | Ad5/3-9HIF- Δ24-VEGFR-1-Ig | Ad | sF-1-Ig | Kidney | Guse K et al. Gen Ther 2009;16:1009–1020 |
| 6 | Ad-ΔB7- shVEGF | Ad | shRNA- VEGF | Glioma | Yoo JY et al. Mol Ther 2007;15:295–302 |
| 7 | AdΔB7-KOX | Ad | F435-KOX | Glioma | Kang YA et al. Mol Ther 2008;16:1033–40 |
| 8 | AdΔ24TIMP3 | Ad | TIMP3 | Glioma | Lamfers ML et al. Cancer Res 2005;65:9398–405 |
| 9 | rQT3 | HSV-1 | TIMP3 | MPNST | Mahller YY et al. Cancer Res 2008;68:1170–9 |
| 10 | CRAD-Cans | Ad | Canstatin | Pancreatic | Xiao-Ping H et al. Cancer Letters 2009;285:89–98 |
| 11 | HSV-Endo | HSV-1 | Endostatin | Colon Carcinoma | Mullen JT et al. Cancer 2004;101:869–77 |
| 12 | AE618 | HSV-1 | Endostatin- Angiostatin fusion Pr. | Lung Cancer | Yang CT et al. Anticancer Res 2005;25;2049–54 |
| 13 | CNHK500- mE | Ad | Mouse Endostatin | Nasopharyngeal tumor | Su C et al. Mol Cancer Res 2008;6:568 |
| 14 | CNHK200- mE | Ad | Endostatin | Hepatocellular carcinoma | Li G et al. Int J Cancer 2005;113:640–-8 |
| 15 | RAMBO | HSV-1 | Vasculostatin | Glioma | Hardcastle J et al. Mol Ther 2009;Oct 20 |
| 16 | bG47Δ-PF4 | HSV-1 | Platelet Factor-4 | Glioma, Malignant Peripheral Nerve Sheath Tumors | Liu TC et al. Mol Ther 2006;14:789–97 |
| 17 | bG47Δ-dnFGFR | HSV-1 | dn Fibroblast growth factor | Glioma, Malignant Peripheral Nerve Sheath Tumors | Liu TC et al. Clin Cancer Res 2006;12:6791–9 |
| 18 | Ad-ΔB7- U6shIL8 | Ad | shRNA-IL-8 | Liver Cancer, and Non small cell lung cancer, Pulmonary metastasis of breast | Yoo JY et al. Gene Ther 2008;15:635–51 |
| 19 | M4 | Ad | Antisense STAT3 cDNA | Gastric Carcinoma | Han Z et al. Carcinogenesis 2009;30:2014–2022 |
Abbreviations: VEGF: Vascular Endothelial growth factor; sflt-1: soluble VEGF receptor flt-1; Ad: Adenovirus; sh-VEGF: small hairpin targeting VEGF; TIMP3: Tissue inhibitor of metaloproteinases; HSV-1: Herpes Simplex virus; dnFGFR: dominant negative Fibroblast growth factor receptor; shIL8: small hairpin targeting IL8; GLAF-1: anti-VEGF single-chain antibody; sF-1Ig: soluble VEGFR 1-Ig; RAMBO: rapid antiangiogenic mediated by oncolytic virus.