. Author manuscript; available in PMC: 2011 Apr 1.

Published in final edited form as: Cytokine Growth Factor Rev. 2010 Apr–Jun;21(2-3):127–134. doi: 10.1016/j.cytogfr.2010.02.014

Table 3.

OV armed with matrix modulating enzymes

OV NAME	VIRUS TYPE	THERAPEUTIC GENE		IN VIVO MODEL	REF.
Collagen Targeting OV:
Ad-ΔE1B- DCNG	Ad	Decorin	Modulation of several ECM components	Glioma, Metastatic Melanoma	Choi IK et al. Gen Ther 2009;Nov 17:1–12
Ad-ΔE1B- RLX	Ad	Relaxin	Collagen modulation	Hepatocellular carcinoma, and lung metastasis	Kim JH et al. J Natl Cancer Inst 2006;98:1482–93