Table 5.
Association between serum IL-6 concentrations and colorectal adenoma recurrence among intervention group participants of the Polyp Prevention Trial (n=872)
| Interleukin-6 Quartiles* (in pg/mL) | Adenoma Recurrence (T4) |
||||||
|---|---|---|---|---|---|---|---|
| No | Advanced | High Risk | Any | ||||
| n (%) | n (%) | OR (95% CI)† | n (%) | OR (95% CI)† | n (%) | OR (95% CI)† | |
| Trial (T1,3) | |||||||
| Q1: >2.80 | 125 (57.6) | 15 (6.9) | 1.00 | 35 (16.1) | 1.00 | 92 (42.4) | 1.00 |
| Q2: 1.99–2.80 | 127 (58.3) | 12 (5.5) | 0.79 (0.34–1.81) | 26 (11.9) | 0.71 (0.39–1.27) | 91 (41.7) | 1.01 (0.68–1.49) |
| Q3: 1.47–1.98 | 131 (60.1) | 16 (7.3) | 1.19 (0.53–2.63) | 26 (11.9) | 0.82 (0.45–1.48) | 87 (39.9) | 1.01 (0.68–1.49) |
| Q4: < 1.47 | 141 (64.4) | 6 (2.7) | 0.51 (0.19–1.41) | 13 (5.9) | 0.45 (0.22–0.92) | 78 (35.6) | 0.95 (0.63–1.42) |
| P-trend‡ | 0.38 | 0.05 | 0.80 | ||||
| Change (T1,3–T0) | |||||||
| Q1: >0.55 | 123 (56.7) | 14 (6.5) | 1.00 | 33 (15.2) | 1.00 | 94 (43.3) | 1.00 |
| Q2: 0.06–0.55 | 129 (59.2) | 17 (7.8) | 1.39 (0.63–3.06) | 24 (11.0) | 0.76 (0.42–1.41) | 89 (40.8) | 0.98 (0.66–1.45) |
| Q3:−0.43–0.05 | 131 (60.1) | 10 (4.6) | 0.83 (0.34–2.00) | 24 (11.0) | 0.79 (0.43–1.45) | 87 (39.9) | 0.98 (0.66–1.45) |
| Q4: < −0.43 | 141 (64.4) | 8 (3.7) | 0.47 (0.19–1.18) | 19 (8.7) | 0.44 (0.23–0.84) | 78 (35.6) | 0.72 (0.48–1.06) |
| P-trend‡ | 0.06 | 0.02 | 0.09 | ||||
Interleukin-6 concentrations in quartiles (Q1–Q4) of the geometric mean values of year 1 and 3 values [Trial (T1,3)] and of the change in IL-concentrations from baseline [Change (T1,3–T0)].
Multivariate OR and 95% CI models were adjusted for age tertiles (<58, 58–66, >66 yrs), sex, average BMI (<25, 25.0–29.9, ≥30 kg/m2), and current smoking status during the first 3 trial years.
The ln[ln(value+1)]-transformed median concentrations of each quartile were used as a continuous score variable to determine the P-value for trend for the IL-6 concentrations at T1,3. The median concentrations of each quartile were used to determine P-value for trend for the change in IL-6 concentrations (T1,3–T0).