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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Cytokine Growth Factor Rev. 2010 Mar 17;21(2-3):197–203. doi: 10.1016/j.cytogfr.2010.02.005

Fig. 1.

Fig. 1

Cap-dependent and IRES-mediated translation initiation. (A) - (C) eIF4E binding to the m7G-cap and binding of eIF4G result in recruitment of 40S ribosomal subunits to eukaryotic mRNAs. (D) Alternatively, IRES-mediated translation occurs without involvement of the 5’ terminus or eIF4E and, at least for poliovirus [47], likely occurs via direct eIF4G binding to the IRES.