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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Nat Nanotechnol. 2010 Apr 11;5(6):465–472. doi: 10.1038/nnano.2010.58

Figure 1. Schematic showing the delivery of payload by gold nanoparticles.

Figure 1

a, Delivery of payload (green ovals) into tumour cylindroids by gold nanoparticles (gold circles). Cells containing released FITC-SH are in green. Viable cells are shown with smooth, solid boundaries, whereas necrotic cells have rough, dashed boundaries. Dotted arrowhead lines indicate diffusion and cellular uptake. In cylindroids, nanoparticles are present in the medium outside the boundary of the cell mass. b, Intratumoral delivery by gold nanoparticles following extravasation from the vessel lumen (red circles). c, Mixed monolayer-protected gold nanoparticles loaded with thioalkylated FITC or doxorubicin (DOX). d, Cellular uptake and FITC-SH release by thiol-mediated replacement reactions.