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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Nat Nanotechnol. 2010 Apr 11;5(6):465–472. doi: 10.1038/nnano.2010.58

Figure 3. Release of FITC-SH from Au-NPs in tumour cylindroids.

Figure 3

a–f, Green fluorescence images and corresponding intensity profiles of cylindroids treated with nanoparticles. Fluorescence images were acquired after incubation with p-FITC-AuNP (a), n-FITC-AuNP (c) and FITC (e) for 11, 21, and 46hrs. Dotted circles indicate cylindroid edges and scale bar is 300mm. In b and d, fluorescence intensity profiles are shown at 11, 21, 38, and 46hrs. g and h, Change of average fluorescence intensities over time in the inner and outer regions of cylindroids (indicated with hashed bars in panel b and d) after incubation with p-FITC-AuNP (g) and n-FITC-AuNP (h). Errors are standard error of the mean (n=3). i, Blue fluorescence image of a cylindroid incubated with OPA for 18hrs. Scale bar is 200μm. j, green confocal fluorescence microscope image of the outer region of the cylindroid treated with p-FITC-AuNP. Scale bar is 20mm.