Figure 4. Doxorubicin release in cylindroids.
a–c, Red fluorescence images and the corresponding radial intensity profiles of cylindroids treated with positive Dox-AuNP (a), negative Dox-AuNP (b) and free Dox (c). Dotted circles indicate cylindroid edges. Scale bars are 200μm. d and e, Ratio of average fluorescence intensities in the outer region to those in the inner region of cylindroids, 30 hours after treatment (d) and as a function of time (e). Errors are standard error of the mean, and significance was determine using Student’s t-test (*, P<0.05; n=3).
