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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Nat Nanotechnol. 2010 Apr 11;5(6):465–472. doi: 10.1038/nnano.2010.58

Figure 5. Effect of surface charge on diffusivity through extracellular matrix material.

Figure 5

a, Schematic representation of loading module filled with Matrigel. b, Green fluorescence images acquired from the bottom of the loading module 4 and 24hrs after adding particles. Dotted lines at both ends indicate Matrigel edges. Scale bar is 500μm. c, Fluorescence intensity profiles in Matrigel along the x-axis as a function of time (symbol) and intensity profiles generated by fitting to a Fickian diffusion model (solid lines). d, Comparison of diffusion coefficients of FITC, cationic and anionic gold nanoparticles in Matrigel (*, P<0.005; n=3).