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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Nat Nanotechnol. 2010 Apr 11;5(6):465–472. doi: 10.1038/nnano.2010.58

Figure 6. Rate constants of cellular uptake and predictions of particle and ligand distribution in tumours.

Figure 6

a and b, Fluorescence intensity profiles measured in fluorescence images of cylindroids (symbol) and those predicted by the mathematical model (solid lines). Concentrations were normalized by the maximum concentration of FITC-AuNP in cylindroids. c, Independent concentration profiles of fluorophore bound to nanoparticles (FITC-AuNP) and released fluorophore ligand (FITC-SH) predicted by the computation model. d, Comparison of forward (k1) and reverse (k2) rate constants between different regions. Errors are standard error of the mean, and significance was determine using Student’s t-test (*, P<0.05). e and f, Modeled concentrations of FITC-AuNPs and released FITC-SH as a function of distance from blood vessels of a hypothetical tumour. Clearance half-life of FITC-AuNPs was assumed to be 3hrs. g, Average concentrations of FITC-AuNPs in the region between 10–70 μm (proliferating) and 75–120 μm (quiescent) from the blood vessel wall as a function of time. h, Average concentrations of released FITC in deep tumour regions (1.0–1.5 mm) as a function of time.